Why are MSCs therapeutic? New data: new insight

Mitophagy: New Insight into the Cardiovascular Aging  

A new window on MSCs.

croenvironment, Wnt3A acts to promote osteoblast differentiation and suppress osteoclastogenesis. This results in inhibition of myeloma bone disease and consequent indirect suppression of tumor growth. These studies advance our knowledge of myeloma bone disease, and raise questions regarding the balance of agonists and antagonists of the Wnt signaling pathway in myeloma, and the function of Wnt...

Why New Software Processes Are Not Adopted

Why do we often appear not to do what is best for us, or at least what someone else thinks is best? To what extent do the reasons have to do with what is being suggested vs. to how the implementation is planned and executed? Is there a way to accelerate the rate at which the implementation of process adoption can be achieved? These questions are addressed by reviewing the considerable literatur...

New insight puts CRAF in sight as a therapeutic target.

By selectively depleting components of the RAF-MEK-ERK pathway in transgenic mice, it is now shown in 2 studies that CRAF is critical for signaling to MEK downstream of oncogenic Kras and that BRAF is not required.

Multiple Verrucous Hemangiomas: A Case Report with New Therapeutic Insight

Verrucous hemangioma is an uncommon congenital vascular malformation, which may clinically masquerade angiokeratoma, lymphangioma circumscriptum, or malignant melanoma. Differentiation is essential owing to varied therapeutic and prognostic implications. We present a rare case of multiple verrucous hemangiomas in a teenage girl who presented with multiple warty lesions over the dorsal aspect of...